Title of article
Convenient synthesis of 2-alkylamino-6-carboxy-5,7-diarylcyclopenteno[1,2-b]pyridines via direct acylamination with imidoyl chlorides
Author/Authors
Hirobumi Takahashi، نويسنده , , Takehiro Fukami، نويسنده , , Hisaki Kojima، نويسنده , , Takeru Yamakawa، نويسنده , , Hiroyuki Takahashi، نويسنده , , Toshihiro Sakamoto، نويسنده , , Teruyuki Nishimura، نويسنده , , Masayuki Nakamura، نويسنده , , Takashi Yosizumi، نويسنده , , Kenji Niiyama، نويسنده , , Norikazu Ohtake، نويسنده , , Takashi Hayama، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
9
From page
3473
To page
3481
Abstract
A robust synthetic method for 2-alkylamino-6-carboxy-5,7-diarylcyclopenteno[1,2-b]pyridines via acylamination at the alpha position of the functionalized pyridine system has been developed. The key step in this method was achieved by treatment of the corresponding pyridine N-oxides with 2.5 equiv of imidoyl chlorides in the presence of triethylamine, thus producing the desired 2-acylaminopyridines in good yields (74–96%).
Keywords
Imidoyl chloride , 2-b]pyridines , Acylamination , ETA antagonist
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088568
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