Title of article
Ferric chloride/tetraethyl orthosilicate as an efficient system for synthesis of dihydropyrimidinones by Biginelli reaction
Author/Authors
Ivica Cepanec، نويسنده , , Mladen Litvi?، نويسنده , , Anamarija Bartolin?i?، نويسنده , , Marija Lovri?، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
6
From page
4275
To page
4280
Abstract
An efficient method for the Biginelli reaction of aldehydes, acetoacetate esters and urea employing tetraethyl orthosilicate in the presence of ferric chloride is described. These improved reaction conditions allow the preparation of a wide variety of substituted dihydropyrimidinones (including sterically encumbered ones) in high yields and purity under mild reaction conditions.
Keywords
Biginelli reaction , Tetraethyl orthosilicate , Dihydropyrimidinones , Ferric chloride
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088646
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