Title of article
Desymmetrization of spiro-activated meso-cyclopropanes via nucleophilic substitution
Author/Authors
Paul Müller، نويسنده , , David Riegert، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
7
From page
4373
To page
4379
Abstract
The spiro-activated cyclopropane undergoes desymmetrization either with Li-thiophenoxide in the presence of a chiral complexing ligand, or with ion pairs formed from thiophenols and aromatic chiral amines. The latter procedure is more efficient and provides the ring-opened thioether in up to 79% yield and up to 60% ee.
Keywords
Chiral ion pairs , chiral ligand , Chinchonine , Nucleophilic substitution , Thiophenoxide
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088655
Link To Document