Nucleophilic aromatic substitution reactions of fluorobenzenechromium complexes with P-chiral secondary phosphine–boranes: synthesis of optically pure P-chiral (dialkyl)arylphosphine–boranes

Optically pure P-chiral (dialkyl)arylphosphine–boranes having high structural diversity were prepared by two- or three-component coupling of fluorobenzenechromium complexes, P-chiral secondary phosphine–boranes, and other nucleophiles. The stereochemical integrity at the P-stereogenic center was completely retained during the SNAr process when the reaction was carried out in THF at low temperature.