Title of article
On the reactivity of ascomycin at the binding domain. Part 3: Reactivity of the binding domain towards diazomethane
Author/Authors
Karl Baumann، نويسنده , , Klemens Hoegenauer، نويسنده , , Hermann Knapp، نويسنده , , Markus Bacher، نويسنده , , Andrea Steck، نويسنده , , Trixie Wagner، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
11
From page
4819
To page
4829
Abstract
A thorough product analysis of the reaction of ascomycin with diazomethane has been performed. Apart from the expected oxiranes (epimeric at C9), a whole range of novel derivatives bearing various modifications in the binding domain were obtained. Proposed mechanisms for their formation and stereochemical aspects are discussed.
Keywords
ascomycin , Diazomethane , Methylene insertion , binding domain , X-ray analysis
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088703
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