Domino hydroformylation–Wittig olefination–hydrogenation

Rhodium-catalyzed hydroformylation in the presence of stabilized phosphorus ylides initiates a domino hydroformylation–Wittig olefination process. When mono-substituted acceptor-stabilized phosphorus ylides were employed, a hydrogenation step succeeds the Wittig olefination to give a domino hydroformylation–Wittig olefination hydrogenation process. For the hydroformylation key step both, linear regioselective hydroformylation of terminal alkenes based on catalyst control as well as diastereoselective hydroformylation based on ortho-diphenylphosphanylbenzoate (o-DPPB)-directed active substrate control could be employed.