Title of article
Stereoselective synthesis of (2R,3S,4S)-3-hydroxy-4-methyl-2-tetradecyl-4-butanolide starting from 2,5-anhydro-d-mannitol
Author/Authors
Shunya Takahashi، نويسنده , , Narihito Ogawa، نويسنده , , Nobuo Sakairi، نويسنده , , Tadashi Nakata، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
6
From page
6540
To page
6545
Abstract
A novel approach to natural β-hydroxy-γ-lactone from 2,5-anhydro-d-mannitol () is described. The key reactions in this synthesis include stereoselective methylation of aldehyde with lithium dimethylcuprate, an intramolecular radical cyclization of seleno carbonate and an intermolecular cross-metathesis of 3-allyl-4-hydroxy-γ-lactone with 1-tridecene.
Keywords
Intermolecular cross-metathesis , 2 , intramolecular radical cyclization , 5-Anhydro-d-mannitol
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088866
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