Title of article
Synthesis and glycosidase inhibitory activity of new penta-substituted C8-glycomimetics
Author/Authors
Olivia Andriuzzi، نويسنده , , Christine Gravier-Pelletier، نويسنده , , Jean-Claude Hausmann and Pierre Vogel، نويسنده , , Yves Le Merrer، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
11
From page
7094
To page
7104
Abstract
The syntheses of new C8-carbasugars and -aminocyclitols related to miglitol and voglibose are described. The key step involves the ring closing metathesis of 1,9-dienes derived from d-mannitol. Chemical transformations of the newly created double bond of the resulting cyclooctenes involved notably hydroboration and reductive amination. The inhibitory activity of the glycomimetics so-obtained has been evaluated towards 24 commercially available glycosidases.
Keywords
Aminocyclitols , Glycomimetics , Ring closing metathesis , Reductive amination , Glycosidases , Carbasugars
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088929
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