Title of article
Synthesis of 2-azaspiro[4.4]nonan-1-ones via phosphine-catalysed [3+2]-cycloadditions
Author/Authors
Sarah R. Yong، نويسنده , , Morwenna C. Williams، نويسنده , , Stephen G. Pyne، نويسنده , , Alison T. Ung، نويسنده , , Brian W. Skelton، نويسنده , , Allan H. White، نويسنده , , Peter Turner، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
10
From page
8120
To page
8129
Abstract
The phosphine-catalyzed [3+2]-cycloaddition of the 2-methylene γ-lactams and and the acrylate with the ylides derived from the ethyl ester, the amide or the chiral camphor sultam derivative of 2-butynoic acid () give directly, or indirectly after reductive cyclization, spiro-heterocyclic products. The acid underwent Curtius rearrangement and then acid hydrolysis to give two novel spiro-cyclic ketones, and .
Keywords
Curtius rearrangement , Spiro-heterocyclics , Phosphine-catalyzed , 2-Methylene ?-lactams
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1089030
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