Title of article
Synthesis of new 8-arylisoquinoline derivatives by application of palladium-catalyzed Suzuki cross-coupling reactions
Author/Authors
Inmaculada Andreu، نويسنده , , Nuria Cabedo، نويسنده , , Frédéric Fabis، نويسنده , , Diego Cortes، نويسنده , , Sylvain Rault، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
6
From page
8282
To page
8287
Abstract
New 8-(het)aryltetrahydroisoquinolines (), 8-aryltetrahydroisoquinolin-4-ols (,), and 8-phenylisoquinolin-4-ol (), flexible analogues of aporphine, were synthesized in good yields using palladium-catalyzed Suzuki cross-coupling reactions from 8-bromotetrahydroisoquinolin-4-one () as a common intermediate. We also describe the synthesis of this novel intermediate through an easy and efficient method, which involved intramolecular Friedel–Crafts cyclization.
Keywords
8-Bromotetrahydroisoquinoline , Friedel–Crafts cyclization , 8-Aryltetrahydroisoquinolines , Suzuki cross-coupling reactions
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1089049
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