Palladium catalyzed Suzuki cross-coupling reactions using N,O-bidentate ligands

Palladium-catalyzed Suzuki cross-coupling reactions employing Schiff-bases as ligands toward a series of substituted arylbromides and boronic acids were pursued. In the presence of a N,O-bidentate ligand, 2-[1-(2,4,6-trimethyl-phenylimino)-ethyl]-phenol , the catalytic reactions could be carried out efficiently at room temperature with a wide array of arylbromides, even with electronically deactivated arenes. A deprotonated , , chelated palladium acetate complex, [Pd(II)(OAc)(solv)] , was proposed as a precursor of a genuine catalytically active species.