Metal catalyzed multicomponent syntheses of secondary propargylamides and oxazoles from silylimines, acid chlorides, and alkynes

Copper(I) and zinc(II) catalyzed routes to construct secondary propargylamides in one-pot procedures from aldehydes, LiN(TMS)2, acid chlorides, and alkynes are described. This reaction has been subsequently used to provide a one-pot synthesis of oxazoles from four simple building blocks.