Title of article
Deracemisation of aryl substituted α-hydroxy esters using Candida parapsilosis ATCC 7330: effect of substrate structure and mechanism
Author/Authors
B. Baskar، نويسنده , , N.G. Pandian، نويسنده , , K. Priya Dasan، نويسنده , , Anju Chadha، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
11
From page
12296
To page
12306
Abstract
Candida parapsilosis ATCC 7330 was found to be an efficient biocatalyst for the deracemisation of aryl α-hydroxy esters (65–85% yield and 90–99% ee). A variety of aryl and aryl substituted α-hydroxy esters were synthesized to reflect steric and electronic effects on biocatalytic deracemisation. The mechanism of this biocatalytic deracemisation was found to be stereoinversion.
Keywords
Chiral HPLC , Candida parapsilosis ATCC 7330 , Deracemisation , Stereoinversion , Alpha hydroxy esters
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1089449
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