Author/Authors :
Zsuzsanna Riedl، نويسنده , , Katrien Monsieurs، نويسنده , , G?bor Krajsovszky، نويسنده , , Petra Dunkel، نويسنده , , Bert U.W. Maes، نويسنده , , P?l Tapolcs?nyi، نويسنده , , Orsolya Egyed، نويسنده , , S?ndor Boros، نويسنده , , Péter M?tyus، نويسنده , , Luc Pieters، نويسنده , , Guy L.F. Lemière، نويسنده , , Gyorgy Hajos، نويسنده ,
Abstract :
New synthetic pathways have been elaborated to 1-methyl-1H-pyridazino[3,4-b]indoles starting from halopyridazin-3(2H)-ones. Suzuki cross-coupling reaction of chloro, iodo, dichloro, and dibromo substituted pyridazin-3(2H)-ones with 2-pivaloylaminophenylboronic acid followed by hydrolysis of the amide and subsequent ring closure via condensation gave fused indoles. Some of these compounds showed biological activity as antitrypanosomal agents.
Keywords :
Fused indoles , Antitrypanosomal activity , Suzuki coupling , Fused pyridazines , ring closure
