Author/Authors :
Julie L. Cavill، نويسنده , , Richard L. Elliott، نويسنده , , D. Gareth Evans، نويسنده , , IAN L. JONES، نويسنده , , James A. Platts، نويسنده , , Antonio M. Ruda، نويسنده , , Nicholas C.O Tomkinson، نويسنده ,
Abstract :
The α-effect can be used as an effective means to promote iminium ion catalysed transformations, providing acyclic scaffolds to aid in catalyst design. A thorough investigation of the structure–activity relationship of the catalyst architecture reveals optimal substituents of a disubstituted carbamate and a secondary alkyl group around a hydrazine scaffold. Molecular modelling investigations provide a mechanistic rationale to the results observed.
