Title of article
A practical diastereoselective synthesis of β-hydroxy-β-trifluoromethyl imines
Author/Authors
Zhenjiang Liu، نويسنده , , Ying-Qiao Mei، نويسنده , , Jin-Tao Liu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
6
From page
855
To page
860
Abstract
The asymmetric carbon–carbon bond formation reaction affording chiral β-hydroxy-β-trifluoromethyl imines is reported involving the nucleophilic addition of sulfinimine anions derived from chiral N-(tert-butanesulfinyl) ketimines to trifluoromethyl ketones. The reaction tolerates a wide range of nucleophiles, giving the condensation products in good to excellent total yields with good diastereoselectivities (up to 85:15 dr).
Keywords
Synthesis , ?-Hydroxy-?-trifluoromethyl imine , Asymmetric , N-(tert-Butanesulfinyl) ketimine , Trifluoromethyl ketone
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1090114
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