Author/Authors :
M. Letizia Ciavatta، نويسنده , , M. Pilar Lopez Gresa، نويسنده , , Margherita Gavagnin، نويسنده , , Vanessa Romero، نويسنده , , Dominique Melck، نويسنده , , Emiliano Manzo، نويسنده , , Yue-Wei Guo، نويسنده , , Rob van Soest، نويسنده , , Guido Cimino، نويسنده ,
Abstract :
Puupehenone (1) and a series of its congeners (2–6) have been isolated from a Dysidea sponge. The unprecedented 20-acetoxy-haterumadienone (2) exhibiting a five-membered contracted ring, has been characterized. In addition, stereochemical assignment of two previously reported acetone adducts of puupehenone (5 and 6) has been made. Finally, the inhibition of mitochondrial respiratory chain as well as antibacterial and antifungal activities of all compounds has been evaluated.
Keywords :
Antibacterial , Mitochondrial respiratory chain , marine metabolites , Sponges , Sesquiterpene-quinones , Antifungal
