Title of article
Reactions of malonthioamides and malonamidines with methyl acetylpyruvate as a one-step method to prepare 4-thio- and 4-aminopyrrolo[3,4-c]pyridines
Author/Authors
Vera S. Berseneva، نويسنده , , Vasiliy A. Bakulev، نويسنده , , Wim Dehaen، نويسنده , , Suzanne Toppet، نويسنده , , Marina Borovkova، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
6
From page
4491
To page
4496
Abstract
We report an efficient one-step approach to 4-thio and 4-aminopyrrolo[3,4-c]pyridines based on the selective reaction of malonthioamides and malonamidines with methyl acetylpyruvate. Structural proof is given by HMBC and HMQC spectra. A cascade heterocyclization mechanism is proposed for the reactions studied.
Keywords
Malonthioamide , Cascade heterocyclization , Methyl acetylpyruvate , HMBC and HMQC spectra , Malonamidine , Fused heterocycles
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1090780
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