Synthetic studies toward plakortide E: application of the Feldman oxygenation to synthesis of highly substituted 1,2-dioxolanes

The Feldman radical oxygenation of vinylcyclopropanes is successfully applied to the synthesis of the highly substituted core of the 1,2-dioxolane natural product, plakortide E. The ratio of the desired cis-1,2-dioxolane can be enhanced by choice of cyclopropane substituents.