Investigation of macrocyclization sites for the synthesis of dendroamide A—an approach from a conformational search

The systematic conformational analysis of three linear precursors for the synthesis of dendroamide A has revealed that these three precursors have the distance between the N- and C-terminal in the range of 3.43–3.93 Å, which suggests the possibility of macrocyclization. This result coincides with the results of the actual synthesis of dendroamide A, but contradicts the reported calculated results.