Author/Authors :
Dinara S. Gunasekera، نويسنده , , Dennis J. Gerold، نويسنده , , Nathan S. Aalderks، نويسنده , , J. Subash Chandra، نويسنده , , Christiana A. Maanu، نويسنده , , Paul Kiprof، نويسنده , , Viktor V. Zhdankin، نويسنده , , M. Venkat Ram Reddy، نويسنده ,
Abstract :
A convenient one-pot synthesis of benzoboroxoles has been developed via the reaction of o-bromobenzyl alcohols with NaH, nBuLi, and B(OiPr)3 followed by acidic hydrolysis. Applications of these benzoboroxoles have been demonstrated in Pd-catalyzed cross-coupling reactions and the protocol has been extended for the synthesis of a chiral benzoboroxole. Exceptionally short synthesis of a potent antifungal agent AN2690 and several of its analogs has also been realized.
Keywords :
Boronic acids , Benzoboroxoles , C–C bond formation , Suzuki–Miyaura cross-coupling , Onychomycosis , Boronate esters
