Title of article :
Synthesis and antiviral properties of aza-analogues of ganciclovir derived from 5,5-bis(hydroxymethyl)pyrrolidin-2-one
Author/Authors :
Mariola Koszytkowska-Stawi?ska، نويسنده , , Ewa Ko?aczkowska، نويسنده , , Ewa Adamkiewicz، نويسنده , , Erik De Clercq، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
Novel aza-analogues of ganciclovir were obtained from 1,5,5-tris(pivaloyloxymethyl)pyrrolidin-2-one by a one-pot base silylation/nucleoside coupling procedure. The compounds were evaluated for, but found to be devoid of, antiviral activity in vitro.
Keywords :
Azanucleosides , N-(Pivaloyloxymethyl)amide , Ganciclovir , Antiviral agents , Pyrrolidinone , Nucleoside analogues
Journal title :
Tetrahedron
Journal title :
Tetrahedron
