Title of article
Regioselective routes towards 14-hydroxyabietane diterpenes. A formal synthesis of immunosuppressant (−)-triptolide from (+)-abietic acid
Author/Authors
Enrique Alvarez-Manzaneda، نويسنده , , Rachid Chahboun، نويسنده , , Faouzia Bentaleb، نويسنده , , Esteban Alvarez، نويسنده , , M. Angeles Escobar، نويسنده , , Said Sad-Diki، نويسنده , , Maria José Cano، نويسنده , , Ibtissam Messouri، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
9
From page
11204
To page
11212
Abstract
Two procedures to introduce an oxygenated function into the C-14 of abietane diterpenes with complete regioselectivity have been developed. Utilizing these, the synthesis of the antileishmanial quinone (−)-12-deoxyroyleanone (1) and a formal synthesis of antitumour and immunosuppressant (−)-triptonide (7) and (−)-triptolide (8) from (+)-abietic acid (13) have been carried out.
Keywords
Hydrazines , Enaminones , Cyclisation , Pyrazoles , Histamine analogues
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1093397
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