Title of article
Design and synthesis of potential β-sheet nucleators via Suzuki coupling reaction
Author/Authors
Elisa Perissutti، نويسنده , , Francesco Frecentese، نويسنده , , Antonio Lavecchia، نويسنده , , Ferdinando Fiorino، نويسنده , , Beatrice Severino، نويسنده , , Francesca De Angelis، نويسنده , , Vincenzo Santagada، نويسنده , , Giuseppe Caliendo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
7
From page
12779
To page
12785
Abstract
Three series of compounds characterized by biphenylic structure were synthesized in order to develop new scaffolds able to induce β-sheet folding in the peptides. Microwave flash heating was used in order to shorten reaction times and to enhance the obtained yields. Simulated annealing molecular dynamics simulations demonstrated that some of the compounds were capable of adopting a 15-membered intramolecularly hydrogen-bonded conformation, which supports an antiparallel β-sheet structure.
Keywords
?-Sheet mimetics , Microwave irradiation , Suzuki coupling
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1093558
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