Title of article
Solution-phase synthesis of ICG-001, a β-turn peptidomimetic molecule inhibitor of β-catenin–Tcf-mediated transcription
Author/Authors
Alessandro Piergentili، نويسنده , , Fabio Del Bello، نويسنده , , Francesco Gentili، نويسنده , , Mario Giannella، نويسنده , , Wilma Quaglia، نويسنده , , Cristian Vesprini، نويسنده , , Russell J. Thomas، نويسنده , , Graeme M. Robertson، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
12912
To page
12916
Abstract
The solution-phase synthesis of the β-turn peptidomimetic ICG-001, a selective inhibitor of Wnt/β-catenin signalling, which has been found to be important for both initiation and progression of cancers of different tissues and has been exploited as an extremely useful chemogenomic tool, was developed. This route is particularly suitable for the multigram scale preparation of ICG-001.
Keywords
Wnt pathway , Solution-phase synthesis , Peptidomimetic , ICG-001 , Inhibitor
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1093572
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