Title of article
Fluoroaziridines as novel substrates in the modified Petasis reaction: synthesis of monofluorinated propargyl amines
Author/Authors
Alexander S. Konev، نويسنده , , Sara Stas، نويسنده , , Mikhail S. Novikov، نويسنده , , Alexander F. Khlebnikov، نويسنده , , Kourosch Abbaspour Tehrani، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
7
From page
117
To page
123
Abstract
Reaction of 2-fluoroaziridines with potassium alkynyltrifluoroborates in the presence of BF3·OEt2 leads to fluorinated propargyl amines in moderate to good yields. The reaction proceeds as an in situ isomerization of 2-fluoroaziridines to α-fluorinated imines, followed by the reaction of the imine with alkynyldifluoroborane, which is generated in situ from the potassium alkynyltrifluoroborates and BF3·OEt2.
Keywords
Boron , Petasis , Fluoroaziridines , Fluorinated amines , Fluorinated aldimines
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1093602
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