Title of article
A Diels–Alder approach to biaryls (DAB): synthesis of the western portion of TMC-95
Author/Authors
Bradley O. Ashburn، نويسنده , , Lauren K. Rathbone، نويسنده , , Elizabeth H. Camp، نويسنده , , Rich G. Carter، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
10
From page
856
To page
865
Abstract
The rapid synthesis of the western biaryl portion of TMC-95 is disclosed via the use of a Diels–Alder reaction with o-nitrostyrene derivative and 1-silyloxy diene with excellent regiochemical control. Subsequent sequential substitutions of a p-iodo-phenol derivative followed by an o-bromo-nitrobenzene intermediate are employed to incorporate the western carbon framework of TMC-95.
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1093676
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