Title of article
A convenient microwave-assisted desulfitative dimethylamination of the 2(1H)-pyrazinone scaffold using N,N-dimethylformamide
Author/Authors
Anuj Sharma، نويسنده , , Vaibhav Pravinchandra Mehta، نويسنده , , Erik Van der Eycken، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
6
From page
2605
To page
2610
Abstract
A convenient microwave-assisted methodology is developed for the generation of 5-chloro-3-(dimethylamino)pyrazin-2(1H)-ones. The method entails a chemoselective desulfitative removal of a phenylthioether bond upon DMF/H2O treatment in the presence of sodium carbonate, yielding the desired compounds in 73–96%.
Keywords
Microwave-assisted organic synthesis (MAOS) , 2(1H)-Pyrazinone , Dimethylamination , DMF , Desulfitative
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1093863
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