Synthesis of 2′-O-α-d-ribofuranosyladenosine, monomeric unit of poly(ADP–ribose)

The first chemical synthesis of 2′-O-α-d-ribofuranosyladenosine, monomeric unit of poly(ADP–ribose), has been achieved starting from 3′,5′-O-bis protected 9-(2-O-α-d-arabinofuranosyl-β-d-ribofuranosyl)-adenine. Configurational inversion of 2′-hydroxyl group of arabinose moiety was performed by oxidation–reduction sequence.