Title of article
New routes to clavine-type ergot alkaloids. Part 2: Synthesis of the last, so far not yet synthesized member of the clavine alkaloid family, (±)-cycloclavine
Author/Authors
M?ria Incze، نويسنده , , G?bor D?rnyei، نويسنده , , Istv?n Moldvai، نويسنده , , Eszter Temesv?ri-Major، نويسنده , , Orsolya Egyed، نويسنده , , Csaba Sz?ntay، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
6
From page
2924
To page
2929
Abstract
Starting from 4-bromo-Uhleʹs ketone (2), an alkylation step using ethyl 3-methylamino-propionate followed by intramolecular aldol condensation in two steps, transformation of the ester group into a methyl group, and finally cyclopropanation of the 8,9 double bond, resulted in a six-step total synthesis of (±)-cycloclavine (1).
Keywords
(±)-Cycloclavine , Modified intramolecular Reformatsky-type cyclization , Total synthesis from 4-bromo-Uhleיs ketone , Cyclopropanation with diazomethane , Clavine alkaloids
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1093893
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