Author/Authors :
Hiroki Kumamoto، نويسنده , , Dimitri Topalis، نويسنده , , Julie Broggi، نويسنده , , Ugo Pradère، نويسنده , , Vincent Roy، نويسنده , , Sabine Berteina-Raboin، نويسنده , , Steven P. Nolan، نويسنده , , Dominique Deville-Bonne، نويسنده , , Graciela Andrei، نويسنده , , Robert Snoeck، نويسنده , , Daniel Garin، نويسنده , , Jean-Marc Crance، نويسنده , , Luigi A. Agrofoglio، نويسنده ,
Abstract :
In our on-going program targeting anti-pox activity, we report here the synthesis of hitherto unknown acyclic nucleoside phosphonates using olefin cross-metathesis (CM) as a key assembly step. Modification at the C-5 position of the uracil moiety was performed under optimized Pd(0)-catalyzed Stille cross-coupling conditions. None of the obtained compounds were active against poxviruses, nor do they exhibit any toxicity.
