Title of article
Abiesanordines A–N: fourteen new norditerpenes from Abies georgei
Author/Authors
Xian-Wen Yang، نويسنده , , Sumei Li، نويسنده , , Lin Feng، نويسنده , , Yun-Heng Shen، نويسنده , , Jun-Mian Tian، نويسنده , , Xiao-Hua Liu، نويسنده , , Hua-Wu Zeng، نويسنده , , Chuan Zhang، نويسنده , , Wei-Dong Zhang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
9
From page
4354
To page
4362
Abstract
Fourteen new norditerpenoids (abiesanordines A–N, 1–14), including a novel podocarpene bearing a rare enolic structure (abiesanordine A, 1), were isolated from Abies georgei together with eight known ones. Their structures were determined mainly by detailed analysis of 1D and 2D NMR spectroscopic data including HSQC, DQF COSY, HMBC, and NOESY. All the isolates were tested for inhibitory activities against LPS-induced NO production in RAW264.7 macrophages, abiesanordine I (9) showed the strongest activity with the IC50 value of 17.0 μg/mL. Furthermore, it exhibited no cytotoxicity against RAW264.7 macrophages under the concentration of 50 μg/mL.
Keywords
Abies georgei , Podocarpenes , Abiesanordines A–N , Pinaceae , Nitric oxide (NO) , RAW264.7 macrophages , norditerpenoids
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1094038
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