Title of article :
Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone
Author/Authors :
Prabhakar Bachu، نويسنده , , Jonathan Sperry، نويسنده , , Margaret A. Brimble، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
The asymmetric synthesis of (−)-9-demethoxyeleutherin 6, (+)-9-demethoxyeleutherin 7 and (+)-7,9-deoxythysanone 8 has been achieved using a microwave assisted kinetic resolution of racemic alcohol 11 with Novozyme 435® as the key step.
Keywords :
Eleutherin , thysanone , Topoisomerase II inhibitor , 3C-protease inhibitor , Microwave assisted lipase kinetic resolution , Intramolecular cyclization , Novozyme 435® (Candida antarctica lipase)
Journal title :
Tetrahedron
Journal title :
Tetrahedron
