Title of article :
Efficient synthesis of α-alkylidene-β-lactams via NaOH-promoted intramolecular aza-Michael addition of α-carbamoyl ketene-S,S-acetals in aqueous media
Author/Authors :
Yang Yang، نويسنده , , Dexuan Xiang، نويسنده , , Xiaoliang Zhao، نويسنده , , Yongjiu Liang، نويسنده , , Jie Huang، نويسنده , , Dewen Dong، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
A facile and efficient synthesis of substituted α-alkylidene-β-lactams have been developed via a NaOH-promoted intramolecular aza-Michael addition of α-carbamoyl, α-(1-chlorovinyl) ketene-S,S-acetals and subsequent nucleophilic vinylic substitution (SNV) reaction in alcoholic aqueous media.
Keywords :
2-azetidinone , Vilsmeier reagent , ?-Lactams , Aqueous media , Michael addition
Journal title :
Tetrahedron
Journal title :
Tetrahedron
