Title of article :
Enantioselective synthesis of α,α-disubstituted α-amino acids by Rh-catalyzed [2+2+2] cycloaddition of 1,6-diynes with protected dehydroamino acid
Author/Authors :
Ken Tanaka and Kanako Ichikawa، نويسنده , , Maho Takahashi، نويسنده , , Hidetomo Imase، نويسنده , , Takuya Osaka، نويسنده , , Keiichi Noguchi، نويسنده , , Masao Hirano، نويسنده ,
Abstract :
We have determined that a cationic rhodium(I)/BINAP complex catalyzes a [2+2+2] cycloaddition of 1,6-diynes with a protected dehydroamino acid, leading to protected α-amino acids bearing a quaternary carbon center in high yield with high enantioselectivity.
