Title of article :
A convenient synthesis and cytotoxic evaluation of N-unsubstituted α-methylene-γ-lactams
Author/Authors :
Henryk Krawczyk، نويسنده , , ?ukasz Albrecht، نويسنده , , Jakub Wojciechowski، نويسنده , , Wojciech M. Wolf، نويسنده , , Urszula Krajewska، نويسنده , , Marek R??alski، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
Chemoselective reduction of 3-aryl-2-diethoxyphosphoryl-4-nitroalkanoates provided the corresponding α-diethoxyphosphoryl-γ-lactams in completely diastereoselective manner. The products were shown to be useful substrates for the synthesis of mono-β-substituted and β,γ-disubstituted α-methylene-γ-lactams. Cytotoxicity of these compounds was evaluated.
Keywords :
?-Diethoxyphosphoryl-?-lactams , ?-Methylene-?-lactams , Horner–Wadsworth–Emmons reaction , Diastereoselective synthesis
Journal title :
Tetrahedron
Journal title :
Tetrahedron
