Author/Authors :
Miwa Azumi، نويسنده , , Kenichi Ogawa، نويسنده , , Tsuyoshi Fujita، نويسنده , , Michinori Takeshita، نويسنده , , Ryuji Yoshida، نويسنده , , Tamotsu Furumai، نويسنده , , Yasuhiro Igarashi، نويسنده ,
Abstract :
Two novel isocoumarins, bacilosarcins A (1) and B (2) were isolated from a culture broth of the marine-derived bacterium Bacillus subtilis TP-B0611. The structures and absolute configurations of 1 and 2 were determined on the basis of spectroscopic analyses and chemical conversions. Compound 1 possesses an unprecedented 3-oxa-6,9-diazabicyclo[3.3.1]nonane ring system while 2 has a 2-hydroxymorpholine moiety that is rare in nature. These compounds showed growth inhibition against barnyard millet.
