Title of article
Practical asymmetric synthesis of a novel γ-secretase inhibitor
Author/Authors
Zheng Wang، نويسنده , , Lynn Resnick، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
6440
To page
6443
Abstract
An efficient route to γ-secretase inhibitor hydroxyl thiophene sulfonamide 1 is described. The approach contains nine steps with an overall yield of 8%. The synthesis highlights a diastereoselective methylation using Evansʹ oxazolidinone method and a chiral Strecker reaction via Davisʹ sulfonimine protocol.
Keywords
?-Secretase inhibitor , Evansי oxazolidinone , Chiral Strecker , Davisי sulfonimine
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1094278
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