Author/Authors :
Chun-Lan Zou، نويسنده , , Le Cai، نويسنده , , Hong Ji، نويسنده , , Guang-Bo Xie، نويسنده , , Feng-Peng Wang، نويسنده , , Xi-Xian Jian، نويسنده , , Lei Song، نويسنده , , Xiao-Yu Liu، نويسنده , , Donglin Chen، نويسنده , , Qiao-Hong Chen، نويسنده ,
Abstract :
A novel approach to the highly functionalized taxane ABC ring system through chemical conversion of the C19-diterpenoid alkaloid deltaline (1) was achieved in six steps (1→17) in 18% overall yield mainly by Grob fragmentation, fission of the Δ9(14) double bond, followed by aldol condensation, and Pelletierʹs cleavage process.
Keywords :
Deltaline , Grob fragmentation , Pelletierיs cleavage , Taxoid , Aldol condensation , C19-diterpenoid alkaloid
