Author/Authors :
Shin-ichi Furuhata، نويسنده , , Yasunao Hattori، نويسنده , , Motonori Okajima، نويسنده , , Hiroyuki Konno، نويسنده , , Masato Abe، نويسنده , , Hideto Miyoshi، نويسنده , , Tetsuhisa Goto، نويسنده , , Hidefumi Makabe، نويسنده ,
Abstract :
Total synthesis of pyranicin and its deoxygenated analogues was achieved using Cl2Pd(CH3CN)2 catalyzed diastereoselective cyclization of the allylic ester as the key step. The inhibitory activity of these compounds for mitochondrial NADH–ubiquinone oxidoreductase (complex I) was poorer than those of ordinary mono-THF acetogenins such as annonacin.
Keywords :
annonaceous acetogenin , Antitumor , Stereoselective synthesis , Mitochondrial complex I
