Title of article
Synthesis of 1-C-linked diphosphate analogues of UDP-N-Ac-glucosamine and UDP-N-Ac-muramic acid
Author/Authors
Andrej Babi?، نويسنده , , Stanislav Gobec، نويسنده , , Christine Gravier-Pelletier، نويسنده , , Yves Le Merrer، نويسنده , , Slavko Pecar، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
8
From page
9093
To page
9100
Abstract
UDP-N-acetyl-glucosamine and UDP-N-acetyl-muramic acid are two important cytoplasmic precursors of bacterial peptidoglycan. The convergent synthesis of their analogues is reported. The α-1-C-linked-N-acetyl-glucosamine was synthesized using microwave-assisted Keck radical allylation. Oxidation of alkene derivatives to the corresponding carboxylic acids allowed attachment to O- and N-sulfamoyluridine giving stable diphosphate mimetics.
Keywords
C-Linked , Diphosphate isosteres , glycosides substrate analogues , Microwave-assisted synthesis
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1094587
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