Author/Authors :
Beatrice Severino، نويسنده , , Ferdinando Fiorino، نويسنده , , Antonella Esposito، نويسنده , , Francesco Frecentese، نويسنده , , Francesca De Angelis، نويسنده , , Elisa Perissutti، نويسنده , , Giuseppe Caliendo، نويسنده , , Vincenzo Santagada، نويسنده ,
Abstract :
In this paper, we describe the synthesis of conformationally constrained dipeptide mimetic derivatives. Microwave flash heating was used in several synthetic steps providing the opportunity to perform the reactions in dramatically shortened time as well as to increase the obtained yields. The efficiency of the methodology makes it useful in order to prepare other dipeptides containing the 4-amino-tetrahydro-2-benzazepin-3-one motif.
Keywords :
constrained amino acids , peptide mimetic , Microwave irradiation , Intramolecular , Friedel–Crafts cyclization
