Isolation of new carbamate- or pyridine-containing natural products, fuzanins A, B, C, and D from Kitasatospora sp. IFM10917

New carbamate or pyridine-containing natural products, fuzanins A (1), B (2), C (3), and D (4), were isolated from the culture supernatant of Kitasatospora sp. IFM10917. These compounds were purified by solvent separation, column chromatography, and preparative HPLC, consecutively. The chemical structure of each compound was established on the basis of a spectroscopic analysis and chemical means. Fuzanin D (4) showed cytotoxicity against DLD-1 cells (IC50, 41.2 μM) and moderate inhibition of Wnt signal transcription at 25 μM.