Title of article
The asymmetric aminohydroxylation route to GABOB and homoserine derivatives
Author/Authors
Michael Harding، نويسنده , , Jennifer A. Bodkin، نويسنده , , Fatiah Issa، نويسنده , , Craig A. Hutton، نويسنده , , Anthony C. Willis، نويسنده , , Malcolm D. McLeod، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
13
From page
831
To page
843
Abstract
The 4-nitrophenyl ether is an efficient directing group in the asymmetric aminohydroxylation reaction of homoallylic ether derivatives. Either regioisomeric product can be obtained with useful levels of enantioselectivity allowing for the short enantioselective synthesis of GABOB and homoserine derivatives. A model based on substrate-catalyst interactions is presented to explain the regio- and enantioselectivity of the aminohydroxylation reactions.
Keywords
Osmium , Asymmetric catalysis , Regioselective , Amino acid , Asymmetric aminohydroxylation
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1095033
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