Title of article
New synthesis of 1-[(3,4-dimethoxyphenyl)methoxymethyl]-6,7-dimethoxyisoquinoline (setigerine), a naturally occurring alkaloid, and some derivatives of papaverine
Author/Authors
Jan Jacobs، نويسنده , , Nguyen Van Tuyen، نويسنده , , A Peter Markusse، نويسنده , , Christian V. Stevens، نويسنده , , Leendert Maat، نويسنده , , Norbert De Kimpe، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
5
From page
1188
To page
1192
Abstract
A novel and improved synthetic route for the preparation of the new alkaloid setigerine, isolated from Papaver setigerum DC, and some new 3,4-dihydropapaverine and papaverine derivatives is reported. This method is based on the side chain chlorination of 1-benzyl-3,4-dihydroisoquinolines using N-chlorosuccinimide (NCS) and subsequent reaction with sodium methoxide in methanol to give the corresponding isoquinolines.
Keywords
1-(Dimethoxyaryl)methylisoquinolines , isoquinolines , Papaverine , Setigerine
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1095076
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