Title of article
Practical synthesis of a peptidomimetic thrombin inhibitor
Author/Authors
Serge Wilmouth، نويسنده , , Christel Bufferne-Perret، نويسنده , , Christine Flouzat، نويسنده , , Grégoire Humblot، نويسنده , , Christiane Ray، نويسنده , , Nadine Simbille، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
2689
To page
2694
Abstract
Compound 1 is a low molecular weight thrombin inhibitor developed for treatment of deep vein thrombosis and cardiovascular diseases. We herein report our efforts to develop a robust, efficient and reproducible process suitable for large-scale synthesis of compound 1.
Keywords
Low molecular weight thrombin inhibitor , ?-Hydroxy amide oxidation , Impurity identification , Peptidomimetic , Process development and scale-up
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1095262
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