Title of article :
Practical synthesis of a peptidomimetic thrombin inhibitor
Author/Authors :
Serge Wilmouth، نويسنده , , Christel Bufferne-Perret، نويسنده , , Christine Flouzat، نويسنده , , Grégoire Humblot، نويسنده , , Christiane Ray، نويسنده , , Nadine Simbille، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
Compound 1 is a low molecular weight thrombin inhibitor developed for treatment of deep vein thrombosis and cardiovascular diseases. We herein report our efforts to develop a robust, efficient and reproducible process suitable for large-scale synthesis of compound 1.
Keywords :
Low molecular weight thrombin inhibitor , ?-Hydroxy amide oxidation , Impurity identification , Peptidomimetic , Process development and scale-up
Journal title :
Tetrahedron
Journal title :
Tetrahedron
