Author/Authors :
Ben W. Greatrex، نويسنده , , Samuel J. Brodie، نويسنده , , Richard H. Furneaux، نويسنده , , Sarah M. Hook، نويسنده , , Warren T. McBurney، نويسنده , , Gavin F. Painter، نويسنده , , Thomas Rades، نويسنده , , Phillip M. Rendle، نويسنده ,
Abstract :
The syntheses of monodisperse lysine dendrimers, capped with two to sixty-four mono-, di- and tri-α-d-mannopyranosyl residues are described. These syntheses used reactive N-hydroxysuccinimide esters to ensure complete reaction of dendrimer amines with the mannosylating reagents. The purities of the dendrimers were established by RP-HPLC and MALDI-TOF mass spectrometry and were found to be excellent. The relative ability of these glycodendrimers to induce dendritic cell maturation was measured, however, no significant trends were observed.
