Title of article :
Novel megastigmanes with lipid accumulation inhibitory and lipid metabolism-promoting activities in HepG2 cells from Sedum sarmentosum
Author/Authors :
Osamu Muraoka، نويسنده , , Toshio Morikawa، نويسنده , , Yi Zhang، نويسنده , , Kiyofumi Ninomiya، نويسنده , , Seikou Nakamura، نويسنده , , Hisashi Matsuda، نويسنده , , Masayuki Yoshikawa، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
Four novel megastigmanes, neosedumosides I (1), II (2), III (3), and IV (4) were isolated from the whole plant of Sedum sarmentosum (Crassulaceae). Absolute stereostructures of these constituents were determined on the basis of chemical and physicochemical evidence. Among them, 1–3 were found to show lipid accumulation inhibitory activity in HepG2 cells. Furthermore, 2 and 3 were found to also show lipid metabolism-promoting activity.
Keywords :
Lipid accumulation inhibitory activity , Lipid metabolism-promoting activity , Crassulaceae , Neosedumoside , megastigmane , Sedum sarmentosum
Journal title :
Tetrahedron
Journal title :
Tetrahedron
