Title of article
Efficient synthesis of morolic acid and related triterpenes starting from betulin
Author/Authors
Pu Zhang، نويسنده , , Jia-Hao Chang، نويسنده , , Jun Liu، نويسنده , , Luyong Zhang، نويسنده , , Hongbin Sun، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
4304
To page
4309
Abstract
Morolic acid (1) is a naturally occurring pentacyclic triterpene whose derivatives exhibit promising anti-HIV and other biological activities. An efficient synthesis of 1 has been accomplished in 11 steps with a total yield of 24% starting from betulin. Some related natural triterpenes including moradiol (4), acridocarpusic acid D (5), acridocarpusic acid E (6), and moronic aldehyde (7) have also been synthesized. Biological assay results showed that 1, 5, and 6 exhibited moderate inhibitory activity against glycogen phosphorylase.
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1095448
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