Clavaminols G–N, six new marine sphingoids from the Mediterranean ascidian Clavelina phlegraea

An exhaustive examination of the chemical constituents of the Mediterranean ascidian Clavelina phlegraea led to the isolation of clavaminols G–N (1–6), a new series of amino alcohols, which expand the family of modified marine sphingoids. Structures of the novel compounds 1–6 have been elucidated by spectroscopic analysis and chemical derivatization; bioactivities of compounds 1–6 have also been investigated and comparison of their pharmacological properties with those of previously isolated clavaminols A–F allowed us to perform an assessment of simple structure–activity relationships.